Human-Immune-System (HIS) humanized mouse model (DRAGA: HLA-A2.HLA-DR4.Rag1KO.IL-2RγcKO.NOD) for COVID-19COVID-19에 대한 인간 면역 시스템(HIS) 인간화 마우스 모델(DRAGA: HLA-A2.HLA-DR4.Rag1KO.IL-2RγcKO.NOD)Article Published on 2022-11-302022-09-11 Journal: Human vaccines & immunotherapeutics [Category] SARS, 유전자 메커니즘, [키워드] Anti-viral B cell Blood candidate vaccine CD4 CD8 Cell clinical condition Cord blood COVID-19 COVID-19 research cytotoxic activity DRAGA mice Efficacy epithelial Express expressing functional granzyme B Hematopoietic stem cell Human human ACE2 receptor human antibodies Human immune system human lung-resident CD8 T cells humanized humanized mice IgG antibody immune immunopathological in vivo infused intra-alveolar lung lung immunopathology lung immunopathology. Lungs lymphocyte mechanism mice microthrombi mounted perforin promote Proteins replicating virus response SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 viral secreted surrogate switching System T cell T cells Therapeutics unique upper respiratory airway Viral proteins [DOI] 10.1080/21645515.2022.2048622 PMC 바로가기 [Article Type] Article
Monitoring SARS-CoV-2 Infection Using a Double Reporter-Expressing VirusArticle Published on 2022-10-262022-11-15 Journal: Microbiology Spectrum [Category] COVID19(2023년), SARS, 진단, 치료기술, 치료제, [키워드] acute respiratory syndrome animal models antiviral therapeutics antivirals biology of SARS-CoV-2 Care caused comparable contagious coronavirus coronavirus disease COVID-19 cultured cells demonstrated detect Express expresse expressing expression level facilitate feasibility fluorescent Genes hACE2 hamster Health human Angiotensin-converting enzyme in vitro In vitro assay in vivo infected cell Infection K18 knowledge limitation luciferase luciferase reporter gene luciferase reporter genes mCherry monitoring neutralizing antibody overcome pandemic pathogenicity Protein recombinant reporter responsible robust SARS-CoV-2 SARS-CoV-2 biology SARS-COV-2 infection transgenic mice Transmission Transmission. Vaccine viral fitness viral infection virus wild-type [DOI] 10.1128/spectrum.02379-22 PMC 바로가기
Why Does the Omicron Variant Largely Spare Olfactory Function? Implications for the Pathogenesis of Anosmia in Coronavirus Disease 2019Article Published on 2022-10-172022-11-16 Journal: The Journal of Infectious Diseases [Category] COVID19(2023년), SARS, 변종, [키워드] ACE2 acute respiratory syndrome alkaline Anosmia cause Cell coronavirus COVID-19 D614G D614G mutation Efficiency Express expressing host cell hydrophobic less Loss of Smell Mucus Mutation olfactory dysfunction Olfactory epithelium olfactory function omicron Omicron variant penetration potential mechanism Prevalence Prevalence. Receptor binding reduce reduced SARS-CoV-2 Support target cell tissue tropism TMPRSS2 transmembrane serine protease variants [DOI] 10.1093/infdis/jiac113 PMC 바로가기
Twitter sentiment analysis: An Arabic text mining approach based on COVID-19Article Published on 2022-10-102022-11-16 Journal: Frontiers in Public Health [Category] 치료기술, [키워드] Analysis approach Arabic changed country COVID-19 COVID-19 pandemic Culture dataset effort Express Facebook Government Gulf handling information Instagram Interaction machine learning machine learning - ML media mitigate natural language processing platform problem public health raw data reporter Research sentiment analysis (SA). social media social media platform social media platforms Spread spread of COVID-19 synthetic Synthetic Minority Over-sampling Technique (SMOTE) technique text text mining transmitted virus was done YouTube [DOI] 10.3389/fpubh.2022.966779 PMC 바로가기
Emotions and Topics Expressed on Twitter During the COVID-19 Pandemic in the United Kingdom: Comparative Geolocation and Text Mining AnalysisArticle Published on 2022-10-052022-11-16 Journal: Journal of Medical Internet Research [Category] COVID19(2023년), SARS, 변종, 치료기술, [키워드] Analysis approach can be used change changed Comparative conditions COVID-19 COVID-19 pandemic declined deep learning deep learning-based method dominant emotion emotion detection epidemiological epidemiological situation Express expressing expression geolocation Government Health increase in measure natural language processing negative emotion Neutral omicron optimism outbreak over pandemic platform positive positive attitude Positive emotion proportion public health sentiment analysis social media text text mining the epidemic thought Topic topic modeling. Twitter United Kingdom vaccination variant [DOI] 10.2196/40323 PMC 바로가기
A ubiquitous bone marrow reservoir of preexisting SARS-CoV-2-reactive memory CD4+ T lymphocytes in unexposed individualsArticle Published on 2022-10-042022-11-15 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 치료기술, 치료제, [키워드] analyzed Blood bone Bone marrow CD4 CD4+ CD4+ T lymphocyte CD69 Cell central memory circulating contribute COVID-19 cross-reactive described detectable Efficacy Express human bone marrow immune response Immunity individual investigated long-lasting membrane memory memory CD4+ T lymphocytes memory T cell nucleocapsid protein peptide Peripheral blood phenotype Plasma cells polyfunctional Primary infection provided SARS-CoV-2 systemic immune response T cell T cells the vaccine tissue-resident memory T cells (Trm). vaccination Vaccines [DOI] 10.3389/fimmu.2022.1004656 PMC 바로가기
A SARS-CoV-2 oral vaccine development strategy based on the attenuated Salmonella type III secretion systemArticle Published on 2022-10-012022-11-15 Journal: Journal of Applied Microbiology [Category] COVID19(2023년), SARS, 변종, 진단, 치료기술, [키워드] administration Analysis antibody Antigen antigens attenuated Salmonella ΔhtrA-VNP Bacterial caused CD44 CD69 COVID-19 vaccine cytometric cytosol delivery effective element elicited Express expression Flow fluorescence microscopy Heterologous IgA IgG in vitro increase in Macrophage mixed bacterial preparations. mutant N-protein NTD Oral vaccine pathogenicity phenotype Plasmid promoter RBD S-protein Safe Salmonella SARS-CoV-2 SARS-CoV-2 antigen SARS-CoV-2 vaccine screened secrete secretion shown Significance Significant significant increase SPI-2 strain T-cell activation T3SS the vaccine type III Vaccine was used [DOI] 10.1111/jam.15720 PMC 바로가기
Awareness regarding COVID-19 and its effects on mental health among pre-professional health sciences students at King Saud bin Abdulaziz University for health sciences in Riyadh and Jeddah, Saudi ArabiaArticle Published on 2022-10-012022-11-16 Journal: Environmental science and pollution research inter [Category] 변종, [키워드] Anxiety association Awareness caused conducted consequence coronavirus COVID-19 cross-sectional Depression Effect exhibiting Express expressed expressing female Gender Health Science health science students highest illnesses information investigated Jeddah King majority Mental mental health outbreak pandemic parent participant physical quarantine questionnaire Saudi Arabia Science separated severe depression SPSS statistical analysis Stress stress. university variant virus was collected was performed [DOI] 10.1007/s11356-022-20934-3 PMC 바로가기
SARS-CoV-2 infects adipose tissue in a fat depot- and viral lineage-dependent mannerArticle Published on 2022-09-292022-11-15 Journal: Nature Communications [Category] SARS, 변종, 진단, [키워드] ACE2 adipose Adiposity anatomical Cell cell death cells cellular response Disease progression Express expression fat fat cell infect Infection Lineage occur pro-inflammatory cytokines risk factor SARS-CoV-2 SARS-COV-2 infection severe COVID-19 susceptibility susceptible the SARS-CoV-2 tissue variant viability visceral [DOI] 10.1038/s41467-022-33218-8 PMC 바로가기
A high-resolution flux-matrix model describes the spread of diseases in a spatial network and the effect of mitigation strategiesArticle Published on 2022-09-242022-11-16 Journal: Scientific Reports [Category] SARS, 변종, [키워드] accompanied Community criterion described disease effective Epidemic epidemiological Express Frequency High-resolution individuals Infection infections Interaction introduced less pandemic parameter parameters predicted Propagation recorded reported representing Spread the epidemic the SARS-CoV-2 Transmission transmission rate Travel USA variant [DOI] 10.1038/s41598-022-19931-w PMC 바로가기